Microfluidic Strategy for Circulating Tumour Cells Analysis in Cancer Patients
(For details, see Analytical Chemistry 86, 2041-2049; Chemical Communications 50, 4813-4815; Scientific Reports 4, Article number: 3716, 10.1038/srep03716).
Project Keywords
Cancer Diagnostics, Circulating Tumor Cells, Electrohydrodynamics, Microfluidics
Project Summary
With cancer mortality rates continuing to rise, the national impact of the cancer is beginning to overwhelm healthcare services. The progression of cancer in patients is characterized by cells that invade locally and metastasize to nearby tissues or travel through the blood stream to set up colonies in the other parts of the body. These cells, accounting for 1-100 cells in about a million peripheral blood mononuclear cells, are known as circulating tumour cells (CTCs). Development of advanced technology for capturing CTCs in blood in the early stage of the metastasis process would be transformative in the treatment of cancer. This project strives to build and test a microfluidic device with the capacity to enable selective capture and sensitive detection of CTCs by incorporating three-dimensional microstructured electrodes within the detection/capture domain of the device.
Project Contacts
| Lead Investigator | Dr Muhammad J. A. Shiddiky; Prof Matt Trau |
| Lead Investigator Web Address | http://www.aibn.uq.edu.au/muhammad-shiddiky |
| Research Group: | Trau Group |
| Contact Email | m.shiddiky@uq.edu.au |